Anxiolytic-n-(1-azabicyclo¬2.2.2|oct-3-yl) benzamides and...

Details Anxiolytic-n-(1-azabicyclo¬2.2.2|oct-3-yl) benzamides and... Anxiolytic-n-(1-azabicyclo¬2.2.2|oct-3-yl) benzamides and...

A - Human Necessities

61

K

167/228

A61K 31/435 (2006.01) A61K 31/445 (2006.01) C07D 453/02 (2006.01)

Patent

CA 1309660

ABSTRACT ANXIOLYTIC N-(1-AZABICYCLO[2.2.2]OCT-3-YL) BENZAMIDES AND THIOBENZAMIDES Compositions containing compounds of general formula I: Image wherein: X represents oxygen or sulphur; R1 represents loweralkyl; R2 represents hydrogen, halo, 4,5-benzo, loweralkoxy, amino, methylamino or dimethylamino; R3 represents hydrogen or loweralkyl; and n is 1 or 2 and their pharmaceutically acceptable acid addition salts have anxiolytic activity. In particular, they have activity against anxiety induced by the withdrawal from ingested substances such as narcotics (eg cocaine), alcohol and nicotine.

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