C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/208, 260/266
C07D 405/00 (2006.01) C07D 263/56 (2006.01) C07D 295/13 (2006.01) C07D 307/79 (2006.01) C07D 311/14 (2006.01) C07D 311/18 (2006.01) C07D 311/58 (2006.01) C07D 317/62 (2006.01) C07D 319/08 (2006.01) C07D 319/18 (2006.01) C07D 319/20 (2006.01) C07D 321/10 (2006.01) C07D 327/06 (2006.01) C07D 405/12 (2006.01) C07D 407/12 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 417/10 (2006.01)
Patent
CA 2004670
DIR 0425 Abstract The invention relates to a group of new piperazine derivatives having formula 1 Image (1) wherein - R1 and R2 independently of each other are hydrogen or an alkyl group having 1-3 C atoms, - n has the value 1 or 2, - X is an optionally substituted bicyclic group, - A is a group -CH2-CH2-, -CH2-CH(CH3)- or -CH(CH3)-CH2- - B is an aryl group or a heteroaryl group which may be substituted with one or more of the following substitu- ents: halogen, trifluoromethyl, nitrile, alkoxy having 1- 3 C-atoms, hydroxy, esterified hydroxy, or alkyl having 1-4 C-atoms, or wherein B is a straight or branched alkyl group having 3-10 C atoms, or a saturated or a partly unsaturated cycloalkyl group having 4-10 carbon atoms or an optionally substituted aralkyl, or an optionally sustituted heteroaralkyl, and salts thereof. These compounds have psychotropic, and more in particular good anxiolytic properties without the blood pressure being reduced.
Hartog Jan
Mos Johannes
Duphar International Research B.v.
Fetherstonhaugh & Co.
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