Apl immunoreactive peptides, conjugates thereof and methods...

Details Apl immunoreactive peptides, conjugates thereof and methods... Apl immunoreactive peptides, conjugates thereof and methods...

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61K 39/00 (2006.01) A61K 39/385 (2006.01) C07K 7/08 (2006.01) C07K 14/47 (2006.01) G01N 33/543 (2006.01) G01N 33/554 (2006.01) G01N 33/564 (2006.01) G01N 33/68 (2006.01) G01N 33/92 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2256449

aPL analogs that (a) bind specifially to B cells to which an aPL epitope binds and are disclosed. Optimized analogs lack T cell epitope(s) are useful as conjugates for treating aPL antibody-mediated diseases. Conjugates comprising aPL analogs and nonimmunogenic valency platform molecules are provided as are novel nonimmunogenic valency platform molecules and linkers. Methods of preparing and identifying said analogs, methods of treatment using said analogs, methods and compositions for preparing conjugates of said analogs and diagnostic immunoassays for aPL antibodies are disclosed.

Analogues de l'anticorps antiphospholipide (aPL) qui (a) se lient spécifiquement aux lymphocytes B auxquels un épitope d'aPL se lie. Des analogues optimisés qui sont exempts du ou des épitopes de lymphocytes T sont utiles comme conjugués pour traiter des maladies dépendantes de l'anticorps aPL. Des conjugués comprenant des analogues d'aPL et des molécules à plate-forme de valence non immunogènes sont décrits, ainsi que de nouvelles molécules à plate-forme de valence non immunogènes et des séquences de liaison, des procédés de préparation et d'identification desdits analogues, de procédés de traitement au moyen desdits analogues, des procédés et des compositions destinés à la préparation de conjugués desdits analogues, et des dosages immunologiques et diagnostiques pour les anticorps aPL.

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