C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/06 (2006.01) A61K 39/00 (2006.01) A61K 39/385 (2006.01) C07C 323/12 (2006.01) C07C 323/52 (2006.01) C07K 7/08 (2006.01) C07K 14/00 (2006.01) C07K 16/18 (2006.01) C07K 17/06 (2006.01) G01N 33/554 (2006.01) G01N 33/564 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2223687
aPL analogs that bind specifically to B cells to which an aPL epitope binds are disclosed. Optimized analogs lacking T cell epitope(s) are useful as conjugates for treating aPL antibody-mediated diseases. Methods of preparing and identifying said analogs, methods of treatment using said analogs, methods and compositions for preparing conjugates of said analogs and diagnostic immunoassays for aPL antibodies are disclosed.
L'invention concerne des analogues d'aPL qui se lient spécifiquement aux cellules B auxquelles se lie un épitope d'aPL. Des analogues optimisés dépourvus d'épitopes de cellules T servent de conjugués pour le traitement de maladies induites par les anticorps aPL. Les procédés de préparation et d'identification de ces analogues, les procédés de traitement recourant à ces analogues, les procédés et compositions de préparation de conjugués de ces analogues et les dosages immunologiques diagnostiques pour les anticorps aPL sont également décrits.
Jones David S.
Marquis David Matthew
Victoria Edward Jess
Yu Lin
Fetherstonhaugh & Co.
La Jolla Pharmaceutical Company
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