Aplidine as an l-type calcium channel enhancer

Details Aplidine as an l-type calcium channel enhancer Aplidine as an l-type calcium channel enhancer

A - Human Necessities

61

K

A61K 38/08 (2006.01) A61K 31/407 (2006.01) A61K 45/06 (2006.01) A61P 9/04 (2006.01) A61P 9/06 (2006.01)

Patent

CA 2288639

This invention relates to a new use discovered for the compound known as Aplidine (dehydrodidemnin B) which has structure (I). Aplidine has been found to be a potent L-type calcium channel enhancer in the human heart. This effect makes Aplidine a very useful drug for the treatment of congestive heart failure, as well as useful for the treatment of atrial fibrillation.

Nouvelle utilisation du composé connu sous le nom d'aplidine (déhydrodimménine B) de formule (I). On a trouvé que l'aplidine est un puissant agent favorisant le canal à calcium de type L dans le coeur humain. Cela fait de l'aplidine un médicament extrêmement utile pour le traitement de l'insuffisance cardiaque globale, et utile pour le traitement de la fibrillation auriculaire.

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