Apo-2 ligand

Details Apo-2 ligand Apo-2 ligand

C - Chemistry, Metallurgy

07

K

C07K 14/52 (2006.01) A61K 38/19 (2006.01) A61P 35/00 (2006.01) C07K 14/525 (2006.01) C07K 14/705 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/19 (2006.01) C12N 15/28 (2006.01)

Patent

CA 2318029

A novel cytokine, designated Apo-2 ligand, which induces mammalian cancer cell apoptosis is provided. The Apo-2 ligand is believed to be a member of the TNF cytokine family. Compositions including Apo- 2 ligand chimeras, nucleic acid encoding Apo-2 ligand, and antibodies to Apo-2 ligand are also provided. Methods of using Apo-2 ligand to induce apoptosis and to treat pathological conditions such as cancer, are further provided.

La présente invention concerne une nouvelle cytokine, appelée Apo-2 ligand, qui provoque l'apoptose des cellules cancéreuses mammifères. On pense par ailleurs que l'Apo-2 ligand fait partie de la famille des cytokines TNF. De même, cette invention concerne des chimères de l'APo-2 ligand, un acide nucléique codant l'Apo-2 ligand ainsi que des anticorps de l'Apo-2 ligand. Enfin, l'invention concerne des procédés d'utilisation de l'Apo-2 ligand pour induire l'apoptose des cellules cancéreuses et pour traiter les états pathologiques tels que le cancer.

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