Apo-2 ligand

Details Apo-2 ligand Apo-2 ligand

C - Chemistry, Metallurgy

12

N

C12N 15/28 (2006.01) A01K 67/027 (2006.01) A61K 38/19 (2006.01) C07K 14/525 (2006.01) C07K 14/705 (2006.01) C07K 16/24 (2006.01) C07K 19/00 (2006.01) C12N 5/18 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2241572

A cytokine, designated Apo-2 ligand, which induces mammalian cell apoptosis is provided. The Apo-2 ligand is believed to be a member of the TNF cytokine family. Compositions including Apo-2 ligand chimeras, nucleic acid encoding Apo-2 ligand, and antibodies to Apo-2 ligand are also provided. Methods of using Apo-2 ligand to induce apoptosis and to treat pathological conditions such as cancer, are further provided.

La présente invention concerne une cytokine, désignée comme coordinat Apo-2, qui déclenche l'apoptose des cellules de mammifères. On pense que le coordinat Apo-2 fait partie de la famille des cytokines FNT. L'invention concerne aussi des compositions comportant des chimères de ce coordinat, un acide nucléique qui le code et des anticorps dirigés contre lui. L'invention concerne enfin des procédés d'utilisation du coordinat Apo-2 servant à déclencher l'apoptose et à traiter des états pathologiques tels que le cancer.

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