Apoe genetic markers associated with age of onset of...

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01) A61K 31/00 (2006.01) A61P 25/28 (2006.01) C12N 15/09 (2006.01)

Patent

CA 2555367

Haplotypes in the APOE gene associated with age of onset of Alzheimer~s Disease are disclosed. Compositions and methods for detecting and using these APOE haplotypes in a variety of clinical applications are disclosed. Such applications include articles of manufacture comprising compounds effective in delaying the age of onset of AD in individuals at risk for developing AD and having one of these APOE haplotypes, methods and kits for predicting the age of onset of AD in an individual at risk for developing AD based upon his/her haplotype profile, and methods for delaying the age of onset of AD in individuals at risk for developing AD based upon their haplotype profile.

La présente invention se rapporte à des haplotypes du gène ApoE associés à l'âge de l'apparition de la maladie d'Alzheimer, ainsi qu'à des compositions et à des méthodes de détection et d'utilisation de ces haplotypes ApoE dans diverses applications cliniques. De telles applications comprennent des articles manufacturés comprenant des composés efficaces pour retarder l'âge de l'apparition de la maladie d'Alzheimer chez les individus présentant le risque de développer la maladie d'Alzheimer et ayant un de ces haplotypes ApoE, des méthodes et des trousses permettant de prévoir l'âge de l'apparition de la maladie d'Alzheimer chez un individu présentant un risque de développer la maladie d'Alzheimer sur la base de son profil d'haplotype et des méthodes permettant de retarder l'âge de l'apparition de la maladie d'Alzheimer chez les individus présentant un risque de développer la maladie d'Alzheimer sur la base de leur profil d'haplotype.

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