Apolipoprotein e polymorphism and alzheimer's disease

Details Apolipoprotein e polymorphism and alzheimer's disease Apolipoprotein e polymorphism and alzheimer's disease

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2111503

The present invention relates to a method for the clinical determination of the risk for the late- onset of Alzheimer's disease of a patient, which comprises, determining the number of copies of the apo E gene allele E4 in a biological sample of said patient using an appropriate E4 probe, wherein zero, one or two copies of E4 indicates level of incidence of late-onset of Alzheimer's disease. The method of the present invention also provides for the prognosis for the treatment of Alzheimer's wherein one copy of E4 indicates a level of choline acetyltransferase reduced by half.

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