Apolipoprotein e transgenic animals and assay methods

A - Human Necessities – 01 – K

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Details

A01K 67/027 (2006.01) C07K 14/775 (2006.01) C12N 15/00 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2290707

The present invention features non-human transgenic animal models for gene function, wherein the transgenic animal is characterized by having altered endogenous apolipoprotein E gene function and a transgene for an exogenous human apolipoprotein E isoform. The transgenic animals may be either homozygous or heterozygous for the transgene. The invention also feature methods for using non-human transgenic animal models for the study of apolipoprotein E-mediated pathologies and the identification of compounds and therapies for such pathologies.

Cette invention concerne des modèles d'animaux transgéniques non humains utilisés pour étudier le fonctionnement génique, l'animal transgénique se caractérisant par le fait qu'il présente un fonctionnement génique altéré de l'apolipoprotéine E endogène et un transgène pour l'isoforme d'apolipoprotéine E humaine endogène. Les animaux transgéniques peuvent être homozygotes ou hétérozygotes pour le transgène. Cette invention concerne également des procédés d'utilisation des modèles d'animaux transgéniques non humains pour étudier les pathologies induites par l'apolipoprotéine E et pour identifier des composés et des thérapies destinées à ces mêmes pathologies.

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