Apoptosis associated protein bbk

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 7/08 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2256372

The present invention is directed to an isolated Bbk protein, nucleotide sequences coding for and regulating expression of the protein, antibodies directed against the protein, and recombinant vectors and host cells containing the genetic sequences coding for and regulating the expression of the protein sequence. The invention is also directed to genomic DNA, cDNA, and RNA encoding the Bbk protein sequence and to corresponding antisense RNA sequences. Antibodies can be used to detect Bbk in biological specimens, including, for example, human tissue samples. The present invention is further directed to methods of treating degenerative disorders characterized in inappropriate cell proliferation or inappropriate cell death. The present invention is further directed to methods for diagnosing degenerative disorders characterized in inappropriate cell proliferation or inappropriate cell death, as well as methods for monitoring the progress of such degenerative disorders.

L'invention concerne une protéine Bbk isolée, des séquences nucléotidiques codant et régulant l'expression de la protéine, des anticorps contre la protéine, des vecteurs recombinés et des cellules hôtes contenant les séquences génétiques codant et régulant l'expression de la séquence protéinique. L'invention concerne également l'ADN, l'ADNc et l'ARN génomiques codant la séquence de la protéine Bbk, ainsi que les séquences d'ARN anti-sens correspondantes. Il est possible d'utiliser les anticorps pour déceler la protéine Bbk dans des échantillons biologiques, y compris par exemple des échantillons de tissus humains. L'invention concerne aussi les procédés de traitement applicables aux troubles dégénératifs caractérisés par une prolifération cellulaire inappropriée ou une mort cellulaire inappropriée. L'invention concerne enfin des procédés pour le diagnostic des troubles dégénératifs caractérisés par cette prolifération et cette mort cellulaire inappropriées, ainsi que des procédés pour contrôler l'évolution des troubles en question.

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