Apoptosis induced by monoclonal antibody anti-her2

Details Apoptosis induced by monoclonal antibody anti-her2 Apoptosis induced by monoclonal antibody anti-her2

C - Chemistry, Metallurgy

12

N

C12N 5/18 (2006.01) A61K 39/395 (2006.01) C07K 14/82 (2006.01) C07K 16/32 (2006.01) C07K 16/46 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2236913

Anti-Her2 antibodies which induce apoptosis in Her2 expressing cells are disclosed. The antibodies are used to "tag" Her2 overexpressing tumors for elimination by the host immune system. Also disclosed are hybridoma cell lines producing the antibodies, methods for treating cancer using the antibodies, and pharmaceutical compositions.

L'invention concerne des anticorps anti-Her2 provoquant l'apoptose dans des cellules exprimant Her2. On utilise ces anticorps afin de "marquer" des tumeurs surexprimant Her2, afin qu'elles soient éliminées par le système immun de l'hôte. L'invention concerne également des lignées cellulaires d'hybridomes produisant ces anticorps, des procédés servant à traiter le cancer au moyen de ces anticorps, ainsi que des compositions pharmaceutiques.

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