Apoptosis inducer

Details Apoptosis inducer Apoptosis inducer

A - Human Necessities

61

K

A61K 31/215 (2006.01) A61K 31/19 (2006.01) A61K 31/192 (2006.01) A61K 31/235 (2006.01)

Patent

CA 2165062

An apoptosis inducer containing at least either a phenanthrene derivative represented by general formula (1) or a salt thereof in a pharmacologically available dose as the active ingredient together with an innocuous pharmacological carrier. In said formula, R represents hydrogen or lower alkyl. The inducer can induce or promote apoptosis and is hence useful in the medicinal field as, for example, carcinostatic, remedy for autoimmune diseases, remedy for liver diseases such as hepatitis and hepatocirrhosis, and cancerous metastasis inhibitor.

Inducteur de l'apoptose renfermant au moins un dérivé de phénanthrène représenté par la formule générale (1), ou sel de ce dérivé, employé sous une dose pharmacologiquement acceptable comme principe actif, accompagné d'un excipient pharmacologiquement neutre. Dans ladite formule, R représente hydrogène ou un alkyle inférieur. Cet inducteur, capable d'induire ou de promouvoir l'apoptose, se révèle utile dans le domaine médical par exemple comme cancérostatique, remède contre les maladies autoimmunes, contre les maladies du foie telle que l'hépatite et la cyrrhose du foie, et comme inhibiteur des métastases cancéreuses.

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