Apoptosis inducing adamantyl derivatives and their usage as...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 295/192 (2006.01) A61K 31/192 (2006.01) A61K 31/343 (2006.01) A61K 31/495 (2006.01) C07C 65/21 (2006.01) C07C 235/84 (2006.01) C07D 307/80 (2006.01)

Patent

CA 2259936

The present invention relates to specific adamantyl or adamantyl group derivative containing retinoid compounds induce apoptosis of cancer cells. These adamantyl retinoid derivatives are useful for the treatment of many cancers and solid tumors, especially androgen--independent prostate cancer, skin cancer, pancreatic carcinomas, colon cancer, melanoma, ovarian cancer, liver cancer, small cell lung carcinoma, non-small cell lung carcinoma, cervical carcinoma, brain cancer, bladder cancer, breast cancer, neuroblastoma/glioblastoma, and leukemia. Also, the invention relates to novel adamantyl or adamantyl group derivative compounds which are useful as active agents for the treatment or prevention of keratinization disorders and other dermatological conditions, and other diseases.

La présente invention concerne un dérivé spécifique d'adamantyle ou de groupe adamantyle contenant des composés rétinoïdes et induisant l'apoptose des cellules cancéreuses. Ces dérivés rétinoïdes d'adamantyle sont utiles dans le traitement de nombreux cancers et tumeurs solides, en particulier le cancer de la prostate non dépendant des androgènes, le cancer de la peau, les carcinomes du pancréas, le cancer du côlon, le mélanome, le cancer des ovaires, le cancer du foie, le carcinome du poumon à petites cellules, le carcinome du poumon qui n'est pas à petites cellules, le carcinome cervical, le cancer du cerveau, le cancer de la vessie, le cancer du sein, le neuroblastome/glioblastome, et la leucémie. L'invention porte également sur de nouveaux composés dérivés d'adamantyle ou de groupe adamantyle utiles comme principes actifs dans le traitement ou la prévention des troubles de la kératinisation et autres affections dermatologiques, et dans le traitement ou la prévention d'autres maladies.

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