C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 311/51 (2006.01) A61K 31/18 (2006.01) A61P 35/00 (2006.01) C07D 207/36 (2006.01) C07D 211/96 (2006.01) C07D 231/18 (2006.01) C07D 261/10 (2006.01) C07D 275/03 (2006.01) C07D 277/36 (2006.01) C07D 285/125 (2006.01) C07D 285/135 (2006.01) C07D 295/155 (2006.01) C07D 295/26 (2006.01) C07D 333/34 (2006.01)
Patent
CA 2747837
Disclosed are compounds of Formula (1), in which A1, Z1, Z1A, Z2, Z2A, L1 and Z3 are as defined in the claims, which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and their use in treating dis-eases during which anti-apoptotic Bcl-2 protein is expressed.
L'invention porte sur des composés de Formule (1) dans laquelle A1, Z1, Z1A, Z2, Z2A, L1 et Z3 sont tels que définis dans les revendications, lesquels inhibent l'activité de protéines Bcl-2 anti-apoptotiques, sur des compositions contenant les composés, et sur leur utilisation dans le traitement de maladies durant lesquelles une protéine Bcl-2 anti-apoptotique est exprimée.
Elmore Steven W.
Hexamer Laura
Kunzer Aaron R.
Park Cheol-Min
Souers Andrew J.
Abbott Laboratories
Torys Llp
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