C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/16 (2006.01) C07K 14/705 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2317057
The present invention relates to a member of the TNF-Ligand superfamily, Apoptosis Inducing Molecule II (AIM II). In particular, isolated nucleic acid molecules are provided encoding the human AIM II protein. AIM II polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of AIM II activity. Also provided are therapeutic methods for treating lymphadenopathy, autoimmune disease, graft versus host disease, and to inhibit neoplasia, such as tumor cell growth.
La présente invention se rapporte à un élément de la super-famille des ligands de TNF, la molécule II induisant l'apoptose (AIM II). Elle se rapporte notamment à des molécules d'acides nucléiques isolées qui codent la protéine AIM II humaine. Elle se rapporte aussi aux polypeptides de la molécule AIM II, ainsi qu'à des vecteurs, cellules hôtes et procédés de recombinaison permettant leur fabrication. L'invention concerne en outre des procédés de sélection permettant d'identifier des agonistes et des antagonistes de l'activité d'AIM II. Enfin, l'invention a trait à des méthodes thérapeutiques visant à traiter la lymphadénopathie, les maladies auto-immunes, les réactions de greffons dirigées contre l'hôte et à inhiber la néoplasie, et notamment la croissance des cellules tumorales.
Ebner Reinhard
Ruben Steven M.
Ullrich Stephen
Yu Guo-Liang
Human Genome Sciences Inc.
Mbm Intellectual Property Law Llp
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