Apoptosis inducing molecule ii and methods of use

Details Apoptosis inducing molecule ii and methods of use Apoptosis inducing molecule ii and methods of use

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/16 (2006.01) A61K 48/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2321186

The present invention relates to a member of the TNF-Ligand superfamily. More specifically, isolated nucleic acid molecules are provided encoding a human Apoptosis Inducing Molecule II (AIM II). AIM II polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of AIM II activity. Also provided are therapeutic methods for treating lymphadenopathy, aberrant bone development, autoimmune and other immune system diseases, graft versus host disease, rheumatoid arthritis, osteoarthritis and to inhibit neoplasia, such as tumor cell growth.

Cette invention concerne un membre de la superfamile des ligands-TNF, et plus spécifiquement, des molécules d'acides nucléiques isolées qui codent une molécule II induisant l'apoptose chez l'homme (AIM II); des polypeptides AIM II, ainsi que des vecteurs, des cellules hôtes et des procédés de recombinaison permettant de les produire. Cette invention concerne également des procédés de criblage permettant d'identifier des agonistes et des antagonistes à l'activité de AIM II; des procédés thérapeutiques permettant de traiter la lymphadénopathie, la croissance osseuse aberrante, les maladies auto-immunes et d'autres maladies du système immunitaire, la réaction du greffon contre l'hôte, la polyarthrite rhumatoïde, l'arthrose et d'inhiber la néoplasie telle que la croissance de cellules tumorales.

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