Apoptosis-mimicking synthetic entities and use thereof in...

A - Human Necessities – 61 – K

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A61K 31/685 (2006.01) A61K 9/00 (2006.01) A61K 9/16 (2006.01) A61K 31/198 (2006.01) A61K 31/661 (2006.01) A61K 47/30 (2006.01) A61K 47/48 (2006.01) A61P 25/00 (2006.01) A61P 37/00 (2006.01) C07F 9/09 (2006.01) C07F 9/40 (2006.01)

Patent

CA 2458720

Synthetic bodies having a three-dimensional structure, sized and shaped to resemble apoptotic cells and apoptotic bodies, and comprising phospho-amino acid-side group carrying entities such as beads, are provided. They can be administered to a patient, to alleviate a variety of disorders such as T-cell mediated disorders (autoimmune conditions), inflammatory disorders neurodegenerative disorders and endothelial dysfunction disorders.

Corps synthétiques à structure tridimensionnelle dont la dimension et la forme leur permet de ressembler à des cellules apoptiques et à des corps apoptiques. Ces corps synthétiques comprennent des entités, telles que des billes, supportant des groupes latéraux d'acide phospho-amino. Ces corps synthétiques peuvent être administrés à un patient pour le soulager de divers troubles tels que des troubles induits par les lymphocytes T (états auto-immuns), les maladies inflammatoires, les maladies neurodégénératives et des troubles relatifs au dysfonctionnement endothélial.

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