G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/68 (2006.01)
Patent
CA 2619759
Methods and assays examining expression of one or more biomarkers in a mammalian tissue or cell sample are provided. According to the disclosed methods and assays, detection of the expression of GalNac-T related molecules, such as GalNac-T14 or GalNac-T3, is predictive or indicative that the tissue or cell sample will be sensitive to apoptosis-inducing agents such as Apo2L/TRAIL and anti-DR5 agonist antibodies. Kits and articles of manufacture are also provided.
L'invention porte sur des procédés et des dosages servant à examiner l'expression d'au moins un biomarqueur dans un tissu mammalien ou dans un échantillon cellulaire. Selon les procédés et dosages de l'invention, la détection de l'expression de molécules apparentées à GalNac-T, telles que GalNac-T14 ou GalNac-T3 permet de prédire ou d'indiquer que le tissu ou l'échantillon cellulaire réagira à des agents inducteurs de l'apoptose, tels que des anticorps agonistes Apo2L/TRAIL et anti-DR5. L'invention porte également sur des kits et des articles ainsi réalisés.
Ashkenazi Avi J.
Wagner Klaus W.
Genentech Inc.
Smart & Biggar
LandOfFree
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