G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/68 (2006.01)
Patent
CA 2619842
Methods and assays examining expression of one or more biomarkers in a mammalian tissue or cell sample are provided. According to the disclosed methods and assays, detection of the expression of GalNac-T related molecules, such as GalNac-T14 or GalNac-T3, is predictive or indicative that the tissue or cell sample will be sensitive to apoptosis-inducing agents such as Apo2L/TRAIL and anti-DR5 agonist antibodies. Kits and articles of manufacture are also provided.
L'invention concerne des analyses et des procédés qui examinent l'expression d'un ou plusieurs biomarqueurs dans un échantillon de cellule ou de tissu de mammifère. Selon les procédés et les analyses en question, la détection de l'expression de molécules liées à GalNac-T, telles que GalNac-T14 ou GalNac-T3, prédit ou indique que l'échantillon de cellule ou de tissu réagira à des agents inducteurs d'apoptose, notamment les anticorps agonistes Apo2L/TRAIL et anti-DR5. L'invention concerne également des kits et des articles de fabrication.
Ashkenazi Avi J.
Wagner Klaus W.
Genentech Inc.
Smart & Biggar
LandOfFree
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