Apoptosis specific tp30 protein

Details Apoptosis specific tp30 protein Apoptosis specific tp30 protein

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 14/47 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2139065

Apoptosis or programmed cell death is a tightly regulated mechanism used by the body to eliminate excess cells in a given tissue. If this mechanism fails, resulting in too may cells, cancer may develop in certain tissues. If the mechanism is overactive, resulting in the destruction of too many cells, tissue degeneration can occur. Therefore being able to identify which cells are destined to undergo apoptosis is critical in allowing clinicians, pathologists and researchers to develop means to detect, diagnose or treat disorders wherein the natural regulation of cell death events is interrupted. The present inventor has identified a 30 kDa protein, designated Tp30, that is specific for cells that are programmed to die. A monoclonal antibody specific for Tp30 has also been identified. The Tp30 protein and monoclonal antibodies thereto are useful in the detection and therapy of disorders wherein the natural regulation of cell death events is interrupted. Such disorders include cancer, bone degeneration, autoimmune diseases, neurodegenerative diseases, cardiovascular disorder, ischemia, HIV-associated illness and kidney malfunction.

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