Apoptotic agents for tumor cells of the nervous system

Details Apoptotic agents for tumor cells of the nervous system Apoptotic agents for tumor cells of the nervous system

A - Human Necessities

61

K

A61K 35/76 (2006.01) C07K 14/035 (2006.01) C12N 7/04 (2006.01)

Patent

CA 2209890

According to the present invention, there are provided apoptotic agents for tumor cells of the nervous system which comprise a vector having the .gamma.1 34.5 gene deleted from the genome of a herpes simplex virus. The vectors are able to cause infection in tumor cells of the nervous system, thereby inducing apoptosis, and also enable virus derivatives with enhanced thymidine-kinase sensitivity to be prepared, thus opening up a way for utilizing a drug for gene therapy.

La présente invention fournit des agents apoptosiques des cellules tumorales du système nerveux comportant un vecteur dont le gène gamma.1 34.5 a été éliminé du génome du virus de l'herpès simplex. Les vecteurs sont capables de causer une infection dans les cellules tumorales du système nerveux, induisant ainsi l'apostose, et de permettre la préparation de virus modifiés plus sensibles à la thymidine-kinase. Il s'agit par conséquent d'une piste pour utiliser un médicament dans la thérapie génique.

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