Apparatus and method for combining in vivo and in vitro testing

A - Human Necessities – 61 – B

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A61B 5/055 (2006.01) A61B 5/00 (2006.01) A61B 5/145 (2006.01) A61K 49/00 (2006.01) B65D 81/00 (2006.01) G01N 21/17 (2006.01) G01N 21/31 (2006.01) G01N 27/00 (2006.01) G01N 33/487 (2006.01) G01N 33/49 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2460898

In vivo testing is painless with minimal risks of infection. The location of analytes in different fluid compartments in the body, and accumulation of the analytes in different concentrations in the fluid compartments, make spectroscopic in vivo testing very inaccurate. The present invention provides a single apparatus and method for combining in vivo testing and in vitro testing. The apparatus comprises one or more source of electromagnetic radiation (EMR) within the wavelength range of 300nm to 2500nm, one or more slots for a biological sample, one or more receptor for a body part, a spectrometer, and electronics. The apparatus optionally contains a computer processor and appropriate software. Either the biological sample or the body part can be irradiated with EMR, and calibration algorithms can be applied to the emerging EMR, to predict analyte concentrations or other parameters related to analytes in biological samples. Measurement of the analytes and other parameters will compensate for some of the limitations of in vivo testing, while capturing the benefits of in vivo testing. 37

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