Apparatus and method for diverse chemical synthesis using...

B - Operations – Transporting – 01 – J

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B01J 19/00 (2006.01)

Patent

CA 2280484

A chemical synthesis apparatus (20) for building chemical compounds including a head assembly (21) having an array of movable nozzles coupled to reservoirs of liquid reagents and a base assembly having an array of reaction wells (26) is described. A transport mechanism aligns selected nozzle columns (41) in the X-direction, independently controllable sliders (100) move nozzle columns (41) in the Y-direction. The first sliding seal (30) and the plurality of second sliding seals (120) form enclosed reaction wells while permitting reagent delivery. A gas inlet (70) and outlet (71) sweep away fumes emitted by reagents. Methods of compound synthesis from chemical components are also provided. The apparatus permits the synthesis of chemical libraries.

L'invention concerne un appareil pour synthèses chimiques (20) servant à former des composés chimiques, qui comporte un ensemble tête (21) doté d'un arrangement de busettes mobiles couplées à des réservoirs de réactifs liquides, et un ensemble base équipé d'un arrangement de puits de réaction (26). Un mécanisme de transport permet d'aligner des colonnes de busettes (41) sélectionnées selon l'axe X, et des coulisses (100) réglables indépendamment permettent de déplacer les colonnes de busettes (41) dans l'axe Y. Le premier joint coulissant (30) et plusieurs deuxièmes joints coulissants (120) permettent de former une enceinte autour des puits de réaction, tout en facilitant l'apport de réactif. Une entrée de gaz (70) et une sortie de gaz (71) permettent d'évacuer des gaz émis par les réactifs. Des procédés de synthèse de composés à partir de composants chimiques sont également prévus. L'appareil permet de mettre en oeuvre une synthèse de banques chimiques.

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