B - Operations – Transporting – 01 – J
Patent
B - Operations, Transporting
01
J
B01J 13/06 (2006.01) A61K 9/127 (2006.01) A61K 41/00 (2006.01) A61K 47/48 (2006.01) A61K 49/18 (2006.01) A61K 49/22 (2006.01)
Patent
CA 2218860
A method and apparatus for making vesicles suitable for use as contrast agents in which a container containing an aqueous suspension phase and a separate gas phase is shaken using reciprocating motion. The reciprocating motion is produced by a shaker arm that moves the container in two, substantially perpendicular directions, with the motion in the first direction being along an arcuate path. The overall path of the motion occurs in a figure-8 pattern. The frequency of shaking is at least approximately 2800 RPM, the length of the shaker arm is at least approximately 6 cm, and the angle through which the shaker arm rotates in the first direction is at least approximately 3°. The total length of travel around the figure- 8 pattern is at least 0.7 cm.
La présente invention concerne un procédé et un appareil permettant de confectionner des vésicules convenant comme agents de contraste. Selon l'invention, un récipient contenant une phase en suspension aqueuse et une phase gazeuse séparée subit une agitation produite par un mouvement alternatif. Le mouvement alternatif est produit par un bras agitateur qui déplace le récipient selon deux directions sensiblement perpendiculaires, le mouvement dans la première direction respectant un parcours arqué. Le trajet d'ensemble du mouvement décrit un "8". La fréquence d'agitation est d'environ 2800 t/mn, la longueur du bras d'agitateur étant approximativement d'au moins 6 cm, et l'angle de rotation du bras agitateur dans le premier axe étant environ d'au moins 3 DEG . La longueur totale du déplacement en "8" est d'au moins 0,7 cm.
Barrette Terrence R.
Mccreery Thomas
Unger Evan C.
Yellowhair David
Imarx Pharmaceutical Corp.
Lantheus Medical Imaging Inc.
Smart & Biggar
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