C - Chemistry – Metallurgy – 12 – M
Patent
C - Chemistry, Metallurgy
12
M
C12M 1/00 (2006.01) A61M 1/02 (2006.01) B01D 61/14 (2006.01) B01D 61/18 (2006.01) B01D 61/20 (2006.01) B01F 13/08 (2006.01) B01L 3/00 (2006.01) C12M 1/12 (2006.01) C12M 1/26 (2006.01) C12M 1/36 (2006.01) C12M 3/00 (2006.01) G01N 1/10 (2006.01) G01N 33/49 (2006.01) G01N 33/50 (2006.01) A61M 1/36 (2006.01) B01F 15/00 (2006.01) G01N 11/00 (2006.01) G01N 35/04 (2006.01) G01N 35/10 (2006.01)
Patent
CA 2160009
A particle separator is provided for collection and manipulation of target particles, e.g., target cells, in a closed sterile field condition. In one embodiment, closed sterile field conditions are maintained from separation through concentration and/or cryo treatment steps and/or transfusion. Preservations of closed sterile field conditions are accommodated by using the same integrally coupled vessel for collection and concentration and transfer via integrally coupled conduits to a vessel for cryopreservation and/or transfusion. In one embodiment, a degree of cell concentration can be achieved, while maintaining closed field conditions, by using a hollow fiber device, preferably in-line between the column and the collection used. In another embodiment, a hollow fiber device is used in place of the column to achieve cell washing. In one embodiment, a plurality of valves are responsive to a data processor for controlling the path of fluid flow through the particle separator. A plurality of sensors are provided for providing sensor signals indicative of fluid flowing through the cell separator. A peristaltic pump is responsive to the microprocessor assembly for controlling the speed and direction of fluid flow through the system. A stir plate assembly is responsive to a signal from the data processor for controllably agitating the contents of the cell separator.
Corpuz Stanley
Emde Michael D.
Heimfeld Shelly
Kalamasz Dale
Maloney Patrick M.
Cellpro Incorporated
Gowling Lafleur Henderson Llp
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