G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 27/26 (2006.01) B01J 19/00 (2006.01) B01L 3/00 (2006.01) G01N 27/447 (2006.01) G01N 30/16 (2006.01) G01N 30/60 (2006.01) G05D 7/06 (2006.01) B01F 13/00 (2006.01) B29C 65/00 (2006.01) B29C 65/48 (2006.01) G01N 30/02 (2006.01) G01N 30/28 (2006.01) G01N 30/38 (2006.01) G01N 30/84 (2006.01)
Patent
CA 2196429
A microchip loboratory system (10) and method provide fluidic manipulations for a variety of applications, including sample injection for microchip chemical separations. The microchip is fabricated using standard photolithographic procedures and chemical wet etching, with the substrate and cover plate joined using direct bonding. Capillary electrophoresis and electrochromatography are performed in channels (26, 28, 30, 32, 34, 36, 38) formed in the substrate. Analytes are loaded into a four-way intersection of channels by electrokinetically pumping the analyte through the intersection (40), followed by a switching of the potentials to force an analyte plug into the separation channel (34).
La présente invention concerne un système de laboratoire à microcircuit (10) et un procédé de manipulation fluide applicables à de nombreux domaines, et notamment l'injection d'échantillon en vue de séparations chimiques par microcircuit. Le microcircuit est fabriqué en utilisant les procédés standards de photolithographie et de chimiogravure humide, le substrat et la plaquette de couverture se joignant par liaison directe. L'électrophorèse capillaire et l'électrochromatographie s'exécutent dans des canaux (26, 28, 30, 32, 34, 36, 38). Les analysats sont introduits dans une croisée de quatre canaux par pompage électrocinétique de l'analysat dans la croisée (40), puis l'application de potentiels électriques force l'analysat à pénétrer dans le canal de séparation (34).
Lockheed Martin Energy Systems Inc.
Macrae & Co.
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