Apparatus and method for preparing microparticles

Details Apparatus and method for preparing microparticles Apparatus and method for preparing microparticles

A - Human Necessities

61

K

A61K 9/50 (2006.01) A61K 31/519 (2006.01) B01F 5/00 (2006.01) B01J 13/06 (2006.01)

Patent

CA 2390284

Apparatus and method for preparing microparticles. An emulsion is formed by combining two phases in a static mixing assembly (730). The static mixing assembly preferably includes a preblending static mixer (732) and a manifold (734). The emulsion flows out of the static mixing assembly into a quench liquid whereby droplets of the emulsion form microparticles. The residence time of the emulsion in the static mixing assembly is controlled to obtain a predetermined particle size distribution of the resulting microparticles.

L'invention concerne un appareil et un procédé permettant de préparer des microparticules. Une émulsion est formée par combinaison de deux phases dans un ensemble de mélange statique (730) comprenant de préférence un mélangeur statique (732) de prémélange et un collecteur (734). L'émulsion s'écoule hors de l'ensemble de mélange statique pour pénétrer dans un liquide de trempe dans lequel des gouttelettes de l'émulsion forment des microparticules. Le temps de séjour de l'émulsion dans l'ensemble de mélange statique est commandé de manière à obtenir une répartition granulométrique prédéterminée des microparticules.

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