Apparatus and method for preparing solid forms with...

Details Apparatus and method for preparing solid forms with... Apparatus and method for preparing solid forms with...

A - Human Necessities

61

K

A61K 9/16 (2006.01) B01J 2/04 (2006.01) B01J 2/18 (2006.01)

Patent

CA 2173221

An improved apparatus and method for preparing solid forms with controlled release of the active ingredient accord- ing to the spray drying and spray congealing techniques. The improvement involves the use of an atomizer utiliz- ing the mechanical vibrations of resonant metal elements or nozzles so as to obtain very small droplets with very short spray length (25-30 cm). These droplets fall to give spherical powder particles owing to the evaporation of the contained solvents or of the quenching solidification of the melted waxy components.

Appareil et procédé perfectionnés de préparation de formes solides à libération lente du principe actif, selon des techniques de séchage par pulvérisation et de congélation par pulvérisation. Le perfectionnement consiste à utiliser un atomiseur faisant appel aux vibrations mécaniques de buses ou d'éléments métalliques à résonance afin de produire de très petites gouttelettes avec une longueur de pulvérisation très faible (25-30 cm). Ces gouttelettes tombent pour produire des particules de poudre sphériques par évaporation des solvants qui y sont contenus ou par la solidification par refroidissement brusque des constituants fondus à base de cire.

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