C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/02 (2006.01) C12M 1/34 (2006.01) C12M 3/02 (2006.01) G01N 33/50 (2006.01) G01N 33/566 (2006.01) G01N 35/00 (2006.01)
Patent
CA 2261740
An apparatus and method for real-time measurement of a cellular response of a test compound or series of test compounds (303) on a flowing suspension of cells (349), in which a homogeneous suspension of each member of a series of cell types (349) is combined with a concentration of a test compound (303), directed through a detection zone (355), and a cellular response of the living cells is measured in real time as the cells in the test mixture are flowing through the detection zone (355). The apparatus may be used in automated screening of libraries of compounds, and is capable of real-time variation of concentrations of test and standard compounds and generation of dose/response profiles within a short timespan.
L'invention porte sur un appareil et un procédé de mesure en temps réel de la réponse cellulaire d'un composé de test ou d'une série de composés de tests (303) sur une suspension de cellules s'écoulant (349), dans lesquels une suspension homogène de chacun des éléments d'une série de types de cellules (349) est combiné à une concentration d'un composé de test (303) envoyé sur une zone de détection (355) tandis que la réponse cellulaire des cellules vivantes est mesurée en temps réel et que les cellules du mélange de test traversent la zone de détection (355). L'appareil, qui peut servir pour le criblage automatique de banques de composés permet de faire varier en temps réel les concentrations de composés de tests et normalisés et d'obtenir des profils dose/réponse en peu de temps.
Okun Alex
Okun Ilya
Axiom Biotechnologies Inc.
Caliper Technologies Corp.
Sim & Mcburney
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