Apparatus and method for therapeutic immunodepletion

Details Apparatus and method for therapeutic immunodepletion Apparatus and method for therapeutic immunodepletion

A - Human Necessities

61

M

167/114, 182/15.

A61M 1/36 (2006.01)

Patent

CA 1198055

APPARATUS AND METHOD FOR THERAPEUTIC IMMUNODEPLETION ABSTRACT OF THE DISCLOSURE A therapeutic apparatus for the removal of a harmful agent from blood is provided in the form of an array of hollow fiber bundles connected in parallel, wherein the interior sur- faces of the individual hollow fibers are coated with a covalently bound proteinaceous or other immunoadsorbent selected for specific removal of the harmful agent. In the disclosed method the apparatus is optionally connected as an extracorporeal shunt between the artery and vein of a patient to be treated and the blood is alternately routed through one fiber bundle while the remaining fiber bundles undergo regeneration. Specific em- bodiments include the removal of rheumatoid factor by covalently bound immunoglobulin G and the removal of digoxin by covalently bound anti-digoxin.

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