Apparatus and method for transdermal delivery of...

A - Human Necessities – 61 – K

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A61K 9/70 (2006.01)

Patent

CA 2562731

An apparatus and method for transdermally delivering a biologically active agent comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the fentanyl-based agent is contained in a biocompatible coating that is applied to the microprojection member. In a further embodiment, the delivery system includes a gel pack having a fentanyl-based agent~containing hydrogel formulation that is disposed on the microprojection member after application to the skin of a patient. In an alternative embodiment, the fentanyl-based agent is contained in both the coating and the hydrogel formulation.

La présente invention se rapporte à un appareil et à un procédé d'administration transdermique d'un agent biologiquement actif, ledit appareil comportant un système d'administration ayant un élément (ou système) à microprotubérances qui comporte une pluralité de microprotubérances (ou une matrice de microprotubérances) qui sont conçues pour percer la couche cornée et pénétrer dans la couche d'épiderme sous-jacente, ou dans l'épiderme et les couches du derme. Dans un mode de réalisation, l'agent à base de fentanyle est contenu dans un revêtement biocompatible qui est appliqué sur l'élément à microprotubérances. Dans un autre mode de réalisation, le système d'administration comprend un paquet de gel ayant un agent à base de fentanyle contenant une formulation hydrogel qui est disposée sur l'élément à microprotubérances après application sur la peau d'un patient. Dans un mode de réalisation encore différent, l'agent à base de fentanyle est contenu à la fois dans le revêtement et dans la formulation hydrogel.

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