Apparatus and method for transdermal delivery of...

A - Human Necessities – 61 – K

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A61K 9/28 (2006.01) A61K 38/18 (2006.01)

Patent

CA 2597931

An apparatus and method for transdermally delivering a biologically active agent comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, an Epoetin-based agent is contained in a biocompatible coating that is applied to the microprojection member. In a further embodiment, the delivery system includes a gel pack having an Epoetin-based agent-containing hydrogel formulation that is disposed on the microprojection member after application to the skin of a patient. In an alternative embodiment, the Epoetin-based agent is contained in both the coating and the hydrogel formulation.

Dispositif et procédé servant à administrer par voie transdermique un agent biologiquement actif composé d'un système d'administration pourvu d'un élément (ou système) de microprojection comportant une pluralité de saillies microscopiques (ou un ensemble de ces saillies) conçues pour perforer la couche cornée afin de pénétrer dans la couche épidermique sous-jacente, ou dans les couches de l'épiderme et du derme. Dans un mode de réalisation, l'agent à base d'Epoëtine est contenu dans un revêtement biocompatible appliqué à l'élément de microprojection. Dans un autre mode de réalisation, ce système d'administration comprend un gel compact dont la formulation consiste en un hydrogel contenant l'agent à base d'Epoëtine et qui est placé sur l'élément de microprojection après application à la peau du patient. Dans encore un autre mode de réalisation, cet agent à base d'Epoëtine est contenu à la fois dans le revêtement et dans la formulation d'hydrogel.

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