Apparatus and method for transdermal delivery of parathyroid...

A - Human Necessities – 61 – K

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A61K 9/70 (2006.01) A61K 9/00 (2006.01) A61K 38/29 (2006.01) A61P 19/08 (2006.01) A61P 19/10 (2006.01)

Patent

CA 2680690

An apparatus and method for transdermally delivering a biologically active agent to prevent or treat osteopenia, comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the PTH-based agent is contained in a biocompatible coating that is applied to the microprojection member.

La présente invention concerne un appareil et un procédé destinés à délivrer par voie transdermique un agent biologiquement actif destiné à prévenir ou traiter l'ostéopénie, lesdits appareil et procédé comprenant un système d'administration pourvu d'un élément (ou d'un système) à micro-saillies incluant une pluralité de micro-saillies (ou des micro-saillies disposées en grille) conçues pour percer la couche cornée jusque dans la couche de l'épiderme sous-jacente, ou dans les couches de l'épiderme et du derme. Sous un mode de réalisation, l'agent à base de PTH est contenu dans un enrobage biocompatible appliqué à l'élément à micro-saillies.

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