Apparatus and method using rotary flow distribution mechanisms

B - Operations – Transporting – 01 – J

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B01J 8/10 (2006.01) B01J 19/00 (2006.01) C07C 229/34 (2006.01) C07C 255/04 (2006.01) C07D 401/02 (2006.01) C07D 471/10 (2006.01) C07D 473/18 (2006.01) C07H 19/06 (2006.01) G21C 1/01 (2006.01)

Patent

CA 2742744

Methods and apparatus for facili-tating the synthesis of compounds in a batch device are presented. Application of the batch type microfluidic devices to the synthesis of radiolabeled compounds is described. These methods and apparatus enable the selective introduction of multiple reagents via an enhanced rotary flow distribution valve through a single inlet port of the synthetic device. The sequential introduction of multiple reagents through a single inlet port allows an optimal delivery of highly concentrated reagents into the reactor and facilitates the synthesis of the desired products with a minimal loss of materials during transfers, which is criti-cal to the synthesis of radiolabeled biomarkers.

L'invention concerne des procédés et un appareil facilitant la synthèse de composés dans un dispositif discontinu. L'invention concerne également la mise en oeuvre de dispositifs microfluidiques de type discontinu dans la synthèse de composés radiomarqués. Les procédés et appareil selon l'invention permettent d'introduire de façon sélective des réactifs multiples par l'intermédiaire d'une vanne de distribution à flux rotatif améliorée à travers un orifice d'entrée unique du dispositif de synthèse. L'introduction séquentielle de réactifs multiples dans un orifice d'entrée unique permet une distribution optimale de réactifs hautement concentrés dans le réacteur et facilite la synthèse des produits souhaités avec une perte minimale de matériaux pendant les transferts, ce qui est essentiel dans la synthèse de marqueurs biologiques radiomarqués.

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