Apparatus and methods for automated assessment of tissue...

G - Physics – 01 – N

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G01N 15/00 (2006.01) C12M 1/34 (2006.01) C12Q 1/00 (2006.01) G01N 1/30 (2006.01) G01N 15/02 (2006.01) G01N 21/84 (2006.01) G01N 33/483 (2006.01) G06T 7/40 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2630820

Methods and apparatus for assessing tissue pathology involve computing an index having a value based upon measures of a plurality of morphological features of cell nuclei in the tissue. The methods may be performed completely automatically or semi-automatically. The index value can be predictive of outcome. The index value may be determined by computing discriminant scores for the cell nuclei based upon values of the measures of morphological features and classifying the nuclei into bins based upon the discriminant score values. The index may be based upon proportions of the nuclei classified in different ones of the bins.

L'invention concerne des procédé et un appareil d'évaluation d'une pathologie tissulaire consistant à calculer un indice ayant une valeur basée sur des mesures de plusieurs caractéristiques morphologiques de noyaux cellulaires dans des tissus. Ces procédés peuvent être mis en oeuvre de façon complètement automatique ou semi-automatique. La valeur indice peut prédire le résultat. Cette valeur indice peut être déterminée par calcul de valeurs discriminatoires pour les noyaux cellulaires basés sur des valeurs de mesures de caractéristiques morphologiques et par classification des noyaux dans des bacs basés sur les valeurs discriminatoires. La liste peut être basée sur des proportions de noyaux classifiés dans les différents bacs.

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