C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2495520
Apparatus and methods are described for detecting target DNA in a biological sample using capture probes and electrically-assisted hybridization. The reaction cell is formed with an attachment surface of aluminum oxide for better thermal and physical properties, and the aluminum oxide surface is coated with anti-DIG antibody to provide a convenient attachment layer for the capture probes allowing their correct orientation, while the capture probes are formed with a DIG-label so that they attach to the surface of the cell through an anti-DIG/DIG linkage.
La présente invention se rapporte à un appareil et à des procédés permettant de détecter de l'ADN cible dans un échantillon biologique au moyen de sondes de capture et d'une hybridation par voie électrique. La cellule de réaction est dotée d'une surface de fixation d'oxyde d'aluminium permettant d'obtenir de meilleures propriétés thermiques et physiques et la surface d'oxyde d'aluminium est recouverte d'un anticorps DIG permettant de constituer une couche de fixation convenant aux sondes de capture et permettant leur orientation correcte, tandis que les sondes de capture sont dotées d'une étiquette DIG permettant leur fixation à la surface de la cellule par l'intermédiaire d'une liaison anti-DIG/DIG.
Chan Duncan Ka-Yun
Lau Lok-Ting
Lin Selma Sau Wah
Yu Cheung Hoi
Hai Kang Life Corporation Limited
Hong Kong Dna Chips Limited
Norton Rose Or S.e.n.c.r.l.,s.r.l./llp
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