Apparatus and methods for detecting inflammation using...

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G01N 33/564 (2006.01) G01N 21/64 (2006.01) G01N 33/53 (2006.01) G01N 33/543 (2006.01) G01N 21/01 (2006.01)

Patent

CA 2750531

Apparatus and methods for detecting an a biomarker indicative of an inflammatory condition, including a capillary tube adapted tor one or more biomarkers to adhere to an interior surface thereof, a light source for energizing quantum dots conjugated with the biomarkers within the capillary tube, and a detection system for detecting and quantifying fluorescent energy emitted by the quantum dots in one or more predetermined wavelength ranges, each wavelength range being correlated to one and only one of the biomarkers. A method of stabilizing the fluorescence intensity of quantum dots is also disclosed.

L'invention concerne un appareil et des procédés de détection d'un biomarqueur qui indique un état inflammatoire, l'appareil comprenant un tube capillaire conçu pour qu'un ou plusieurs biomarqueurs adhèrent à une surface intérieure de celui-ci, une source de lumière pour exciter des points quantiques conjugués aux biomarqueurs à l'intérieur du tube capillaire, et un système de détection pour détecter et quantifier l'énergie fluorescente émise par les points quantiques dans une ou plusieurs plages de longueur d'onde prédéfinies, chaque plage de longueur d'onde étant corrélée à un seul des biomarqueurs. L'invention concerne également un procédé de stabilisation de l'intensité de fluorescence des points quantiques.

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