C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2368315
An apparatus (22) is provided for monitoring small molecule-biomolecule interactions. An oscillating substrate (10) has a wet surface (46) for contact with a liquid and for binding with a biomolecule and a dry surface (48). A detection apparatus (42, 44) determines the resonance frequency of said substrate before and after interaction. Thus, small molecules are monitored for interaction with biomolecules by contacting a solution containing the small molecule with immobilized biomolecules under test, and generating acoustic waves using an acoustic wave device. Interaction of the small molecules with the immobilized biomolecules causes a change in frequency, which can be detected and analyzed electronically to monitor the interaction.
L'invention concerne un appareil (22) permettant de contrÙler les interactions entre une petite mol~cule et une biomol~cule. Un substrat (10) oscillant comprend une surface humide (46) permettant le contact avec un liquide et la liaison avec une biomol~cule ; et une surface sche (48). Un appareil de d~tection (42, 44) d~termine la fr~quence de r~sonance dudit substrat avant et aprs l'interaction. Ainsi des petites mol~cules sont contrÙl~es, en vue de l'interaction avec des biomol~cules ; ce contrÙle est effectu~ par contact d'une solution contenant lesdites petites mol~cules avec les biomol~cules immobilis~es soumises ~ un test ; et par cr~ation d'ondes sonores ~ l'aide d'un dispositif ~ ondes sonores. L'interaction entre les petites mol~cules et les biomol~cules immobilis~es provoque un changement de fr~quence, lequel changement peut Útre d~tect~ puis analys~ de manire ~lectronique afin de contrÙler ladite interaction.
Mcgovern Mark
Thompson Michael
Borden Ladner Gervais Llp
Sensorchem International Corporation
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