A - Human Necessities – 61 – M
Patent
A - Human Necessities
61
M
167/114, 167/285
A61M 1/32 (2006.01) A61K 9/00 (2006.01) A61K 9/10 (2006.01) A61K 31/02 (2006.01)
Patent
CA 1288045
APPARATUS AND PROCESS FOR OXYGENATION OF LIQUID STATE DISSOLVED OXYGEN-CARRYING FORMULATION Abstract of the Disclosure Perfluorocarbon emulsion formulations are oxygenated prior to use by means of a portable oxygenation system. The blood substitute is in a closed container or bag. An oxygen-containing gas is introduced into the bag from a separate container. The bag is continuously agitated for a sufficient time to increase the PO2 Of the perfluorocarbon emulsion formulations to a desired pressure, e.g., to at least 600 mmHg. In one embodiment, the system used for oxygenation of the perfluorocarbon emulsion formulations comprises a small tank for gas having an inlet port and an outlet port fitted with shut-off valves. The outlet port is adapted to be connected to a filter which, in turn, is adapted to be connected to the inlet port of a three-way valve. The primary outlet of the three-way valve is adapted to mount a hypodermic needle which is adapted to be pushed through a rubber septum in a port of the bag to communicate with the interior of the bag. The tank is adapted to be filled with oxygen-containing gas, such as carbogen, from a main gas source under pressure. The tank, filter, three-way valve and needle arrangement are connected in series, and the oxygen-containing gas is permitted to flow from the tank into the bag holding the emulsion formulation. After the gas is introduced into the bag, the three-way valve is closed to prevent leakage of the gas from the container. The container is then agitated to oxygenate the emulsion formulation.
547501
Crowe Kim Christensen
Davis Charles Harry Jr.
Groveman George Raymond
Heldebrant Charles Michael
Alliance Pharmaceutical Corp.
Oyen Wiggs Green & Mutala Llp
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