Apparatus for electroporation through microporated tissue

Details Apparatus for electroporation through microporated tissue Apparatus for electroporation through microporated tissue

A - Human Necessities

61

N

A61N 1/32 (2006.01) A61N 1/30 (2006.01)

Patent

CA 2329169

An apparatus for electroporating tissue. At least one micropore (M1,M2) is formed to a predetermined depth through a surface of the tissue (TS), and electrical voltage is applied between an electrode (210) electrically coupled to the micropore and another electrode (212) spaced therefrom. By applying electroporation to tissue that has been breached by a micropore, the electroporation effects can be targeted at tissue structures beneath the surface, such as capillaries, to greatly enhance the withdrawal of biological fluid, and the delivery for uptake of compounds into the tissue. In a preferred embodiment, a device is provided having elements that are suitable for microporating the tissue and which serve as the electroporation electrodes.

Cette invention se rapporte à un appareil servant à effectuer une électroporation à travers un tissu. A cet effet, au moins un micropore (M1, M2) est formé à une profondeur prédéterminée dans une surface du tissu (TS) et une tension électrique est appliquée entre une électrode (210) couplée électriquement à ce micropore et une autre électrode (212) distante de la première. En pratiquant une électroporation sur un tissu qui est traversé par un micropore, on peut cibler les effets de l'électroporation sur des structures du tissu qui se trouvent sous la surface du tissu, par exemple les capillaires, afin d'augmenter considérablement le prélèvement de fluide biologique ou l'apport de composés dans le tissu en vue de leur assimilation. Dans un mode de réalisation préféré, on présente un dispositif comportant des éléments propres à réaliser la microporation du tissu et servant d'électrodes d'électroporation.

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