G - Physics – 01 – N
Patent
G - Physics
01
N
358/12, 73/55
G01N 21/64 (2006.01) G01J 3/00 (2006.01)
Patent
CA 1185705
ABSTRACT OF THE DISCLOSURE Apparatus for conducting fluorescent spectroscopy with sensitivity levels sufficient for precise fluorescence immunoassay measurement on extremely dilute solutions. An improved filter assembly rotatable between a test position and a reference position. The filter assembly includes a pair of test filters, one passing excitation light at one wavelength and the other passing fluorescent light from a test solution at a second wavelength, a pair of reference filters, each passing light at the first wavelength, and light shielding means to block stray light and prevent it from optically coupling between the filters. A pre-filter minimizes the background transmitted light. Insertion of the filter assembly into a commercially available automated clinical photometer enables the instrument to be used as a filter fluorimeter. The disclosure also describes a method for conducting fluorescent spectroscopy which involves irradiating a test sample with light of a first wavelength which causes the test sample to fluoresce light of a second wavelength and measuring a portion of the fluorescent light; irradiating the test sample with light of the first wavelenght at reduced intensity and measuring the light of the first wavelength transmitted through the test sample; and comparing the intensity of the fluorescent light to the transmitted light. The invention also includes apparatus for carrying out the above method. The methods and apparatus of this ivention are particularly useful in clinical chemistry.
399942
Abbott Laboratories
Macrae & Co.
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