Apparatus for sealing a vascular puncture

Details Apparatus for sealing a vascular puncture Apparatus for sealing a vascular puncture

A - Human Necessities

61

L

A61L 31/14 (2006.01) A61L 27/52 (2006.01)

Patent

CA 2583235

Apparatus for sealing a puncture communicating with a blood vessel includes a porous carrier formed from lyophilized hydrogel or other material. The plug may include at least first and second hydrogel precursors and a pH adjusting agent carried by the porous carrier in an unreactive state prior to exposure to an aqueous physiological environment. Once exposed to bodily fluids, the carrier expands as the lyophilized material hydrates to enhance and facilitate rapid hemostasis of the puncture. When the plug is placed into the puncture, the natural wetting of the plug by bodily fluids (e.g., blood) causes the first and second precursors to react and cross-link into an adhesive or "sticky" hydrogel that aids in retaining the plug in place within the puncture.

L~invention concerne un appareil pour sceller une ponction communiquant avec un vaisseau sanguin comprenant un porteur poreux constitué d~hydrogel lyophilisé ou d~un autre matériau. Le bouchon peut comporter au moins un premier précurseur hydrogel et un second précurseur hydrogel et un agent de réglage de pH transporté par le porteur poreux dans un état non réactif avant exposition à un environnement physiologique aqueux. Après exposition aux fluides corporels, le porteur se dilate tandis que le matériau lyophilisé s~hydrate pour améliorer et faciliter l~hémostase rapide de la ponction. Lorsque le bouchon est placé dans la ponction, l~humectation naturelle du bouchon par les fluides corporels (par exemple le sang) conduit le premier et le second précurseurs à réagir et réticuler pour produire un hydrogel adhésif ou "collant" contribuant à retenir le bouchon en place dans la ponction.

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