Apparatus for the synthesis of chemical compounds

Details Apparatus for the synthesis of chemical compounds Apparatus for the synthesis of chemical compounds

C - Chemistry, Metallurgy

07

H

23/375, 195/1.12

C07H 21/00 (2006.01) B01J 19/00 (2006.01)

Patent

CA 1220747

148-108 IMPROVED APPARATUS FOR THE SYNTHESIS OF CHEMICAL COMPOUNDS ABSTRACT OF THE DISCLOSURE An improved apparatus for the synthesis of more complex oligonucleotide compounds from simpler chemical compounds wherein at least one of said simpler chemical compounds is carried on a solid matrix comprising a plurality of beads located within a reaction chamber and is sequentially subjected to a plurality of other simpler chemical compounds passed through the chamber in a stream, causing chemical interaction between the simpler chemical compounds to form said more complex compounds. A novel process which comprises the introduction into a primary reaction zone containing therein a solid support, a plurality of fully activated nucleosides and permitting said plurality of nucleosides to react simultaneously on said solid support to form an oligonucleoside.

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