Apparatus for treating a tumor or the like and articles...

A - Human Necessities – 61 – N

Patent

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A61N 1/40 (2006.01)

Patent

CA 2499845

An apparatus is provided for selectively destroying dividing cells in living tissue formed of dividing cells and non-dividing cells. The dividing cells contain polarizable intracellular members and during late anaphase or telophase, the dividing cells are connected to one another by a cleavage furrow. The apparatus includes insulated electrodes to be coupled to a generator for subjecting the living tissue to electric field conditions sufficient to cause movement of the polarizable intracellular members toward the cleavage furrow in response to a non-homogeneous electric field being induced in the dividing cells. The movement of the polarizable intracellular intracellular members towards the cleavage furrow causes the breakdown thereof which adversely impacts the multiplication of the dividing cells. Preferably, an intervening member is disposed between each insulated electrode and the skin surface and each intervening member includes a conductive "floating" plate that protects against the effects on the patient from a breakdown in the insulation of the electrode.

L'invention concerne un dispositif permettant de détruire sélectivement des cellules mitotiques dans un tissu vivant constitué de cellules mitotiques et de cellules non mitotiques. Ces cellules mitotiques contiennent des éléments intracellulaires polarisables; pendant l'anaphase ou la télophase tardive, les cellules mitotiques sont reliées les unes aux autres par un sillon de clivage. Le dispositif décrit dans cette invention comprend des électrodes isolées conçues pour être couplées à un générateur pour soumettre le tissu vivant à des conditions de champ électrique suffisantes pour provoquer le déplacement des éléments intracellulaires polarisables vers le sillon de clivage en réaction à un champ électrique non homogène induit dans les cellules mitotiques. Le déplacement des éléments intracellulaires polarisables vers le sillon de clivage provoque leur décomposition, ce qui a un effet négatif sur la multiplication des cellules mitotiques. De préférence, un élément intermédiaire est disposé entre chaque électrode isolée et la surface de la peau; chaque élément intermédiaire comprend une plaque conductrice "flottante" qui protège le patient contre les effets d'une défaillance de l'isolation de l'électrode.

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