Apparatuses for renal neuromodulation

A - Human Necessities – 61 – N

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A61N 1/08 (2006.01)

Patent

CA 2583463

Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.

L'invention concerne des méthodes et un appareil pour une neuromodulation rénale. Ces méthodes et cet appareil font appel à un champ électrique pulsé pour effectuer une électroporation ou une électrofusion. Il s'avère qu'une neuromodulation rénale (par exemple, dénervation), peut, entre autres, réduire la dilatation d'un infarcissement myocardique aigu, réduire ou prévenir le déclenchement de changements morphologiques associés à une insuffisance cardiaque congestive, et/ou être efficace dans le traitement d'une maladie rénale en phase finale. Des modes de réalisation de l'invention sont conçus pour administrer de manière intravasculaire et percutanée des champs électriques pulsés pour obtenir une telle neuromodulation.

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