C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 1/00 (2006.01) C12N 1/21 (2006.01) C12N 15/09 (2006.01) C12N 15/52 (2006.01) C12N 15/67 (2006.01) C12P 13/22 (2006.01)
Patent
CA 2220100
This invention describes methods for enhancing carbon flow into a pathway of a host cell to enhance the biosynthetic production of compounds therefrom, the host cells being selected based on being phenotypically Pts-/glucose+. Such host cells are capable of transporting glucose without consuming PEP, resulting in conservation of PEP which can be re-directed into the pathway in order to enhance the production of desired compounds along the pathway. Pts-/glucose+ mutants have been shown to be advantageous for the enhanced production of the aromatic amino acids.
L'invention concerne des procédés permettant d'accentuer le flux de carbone dans une voie d'une cellule hôte ainsi que la production biosynthétique de composés à partir de ceux-ci, les cellules hôtes sélectionnées étant phénotypiquement du Pts<->/glucose<+>. Ces cellules hôtes sont capables de transporter le glucose sans consommer de PEP, ce dernier étant ainsi conservé et pouvant être réorienté dans la voie pour augmenter la production des composés voulus le long de ladite voie. On a constaté que les mutants de Pts<->/glucose<+> sont avantageux pour la production accentuée d'acides aminés aromatiques.
Berry Alan
Mejia Noemi
Valle Fernando
Genencor International Inc.
Gowling Lafleur Henderson Llp
Universidad Nacional Autonoma de Mexico
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