Application of light at plural treatment sites within a...

A - Human Necessities – 61 – N

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A61N 5/06 (2006.01) A61B 18/22 (2006.01)

Patent

CA 2335575

Light is administered during photodynamic therapy (PDT) for an extended period of time at a plurality of sites (52) distributed within the abnormal tissue of a tumor (22). A clinical study has shown that a substantially greater volume of abnormal tissue in a tumor is destroyed by the extended administration of light therapy from a plurality of probes (50a-50e) than would have been expected based upon the teaching of the prior art. In this process, a plurality of light emitting optical fibers or probes are deployed in a spaced apart array. The greater volume of necrosis (38) in the tumor (22) is achieved due to one or more concomitant effects, including the inflammation of damaged abnormal tissue, and resultant immunological response of the patient's body; and the collapse of the vascular system that provides oxygenated blood to portions of the tumor outside the expected fluency zone.

Lors de la thérapie photodynamique (TPD), on augmente la durée d'administration de la lumière au niveau d'une pluralité de sites (52) répartis à l'intérieur du tissu anormal d'une tumeur (22). Une étude clinique a montré que l'on peut, en allongeant le temps d'administration de la photothérapie par une pluralité de sondes (50a-50e), détruire un volume sensiblement plus grand de tissu anormal dans une tumeur qu'on n'aurait pu s'y attendre avec la technique utilisée jusqu'ici. Selon la technique de l'invention, une pluralité de fibres optiques ou sondes émettrices de lumière sont déployées dans une matrice à distance. L'augmentation du volume de nécrose (38) à l'intérieur de la tumeur est due à un ou à plusieurs effets concomitants, qui sont notamment l'inflammation du tissu anormal lésé et la réponse immunologique provoquée dans l'organisme du patient; ainsi que l'effondrement du système vasculaire qui amène le sang oxygéné aux parties de la tumeur situées à l'extérieur de la zone de fluence attendue.

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