Application of superoxide dismutase in liposomes

Details Application of superoxide dismutase in liposomes Application of superoxide dismutase in liposomes

A - Human Necessities

61

K

A61K 38/44 (2006.01) A23L 1/015 (2006.01) A23L 3/3463 (2006.01) A61K 8/64 (2006.01) A61K 9/127 (2006.01) A61K 9/72 (2006.01) A61K 47/36 (2006.01) A61P 17/02 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) A61P 39/06 (2006.01) A61Q 17/04 (2006.01) A61Q 19/00 (2006.01) A01N 1/02 (2006.01)

Patent

CA 2204493

Superoxide dismutase (SOD), preferably rhSOD, is used in liposomes, optionally mixed with hyaluronic acid and/or at least one physiologically acceptable carrier, and other optional additives, to prepare a pharmaceutical composition useful against increased concentrations of superoxide radicals and/or the damage caused thereby. These compositions can be administered topically, orally and/or parenterally to prevent and/or heal in particular burns, skin lesions due to radiation, inflammations, rheumatic and arthritic diseases, bronchitis, ARDS, emphysema, allergic oedemas and other inflammatory process, possibly triggered by microbial infections. They may also be used in the cosmetic treatment of furuncles, acne and the like. Also disclosed is a process for improving the preservability of organic, preferably biogenic, materials, in particular organ transplants and liquids with organic components, as well as foodstuffs, by using the disclosed compositions.

L'invention concerne l'utilisation de la superoxide dismutase (SOD), de préférence la rhSOD, dans des liposomes, le cas échéant mélangée avec l'acide hyaluronique et/ou au moins un excipient physiologiquement acceptable, et facultativement avec d'autres additifs, pour préparer une composition pharmaceutique utile pour combattre une concentration accrue de radicaux superoxides et/ou les lésions causées par ceux-ci. Ces compositions sont à administrer par voie topique, orale et/ou parentérale en thérapie et/ou en prophylaxie en particulier de brûlures et de lésions de la peau dues à des rayonnements, d'inflammations, de maladies rhumatismales et arthritiques, de la bronchite, de la pneumonie interstitielle atypique des bovins, d'emphysèmes, d'oedèmes allergiques et d'autres processus inflammatoires, déclenchés le cas échéant par des infections microbiennes. Ces compositions sont également utiles pour le traitement cosmétique de furoncles, d'acné et similaires. L'invention concerne en outre un procédé qui permet d'améliorer la durabilité de matériaux organiques, de préférence biogéniques, notamment des transplants d'organes et des liquides contenant des composants organiques, ainsi que des denrées alimentaires, grâce à l'utilisation des compositions décrites.

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