Aprotinin analogues

Details Aprotinin analogues Aprotinin analogues

C - Chemistry, Metallurgy

12

N

C12N 15/15 (2006.01) A61K 38/57 (2006.01) C07K 14/81 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2092920

2092920 9206111 PCTABS00011 An aprotinin analogue with reduced nephrotoxicity, wherein, to provide a reduced positive net charge, at least one positively charged amino acid residue outside the protease-binding site is removed or replaced with a neutral or negatively charged amino acid residue, and/or wherein at least one negatively charged amino acid residue is inserted or added, and/or wherein at least one neutral amino acid residue is replaced with a negatively charged amino acid residue, and/or wherein, to provide reduced stability, one or more amino acid residues are deleted, added or replaced with one or more other amino acid residues.

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